Unfolded protein response in keratinocytes: impact on normal and abnormal keratinization.

Abstract excerpt

The unfolded protein response (UPR) is a signaling pathway from the endoplasmic reticulum (ER) to the nucleus that protects cells from stress caused by misfolded or unfolded proteins. As such, ER stress is an ongoing challenge for all cells, given the central biologic importance of secretion as part of normal physiologic functions. Mild UPR is activated by mild ER stress, which occurs under normal conditions....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Darier Disease
• Share to Endoplasmic Reticulum Stress
• Share to Ichthyosis