Article

A lipid-driven, microbe-independent mechanism of acne via <i> Lrig1 <sup>+</sup> </i> follicular progenitor cells

2025-08-31

Abstract excerpt

Long-chain saturated fatty acids (lcSFAs) are abundant in the skin, but their pathogenic roles in acne remain unclear. In human sebum profiling, C16:0, the most abundant lcSFA, was the only fatty acid significantly elevated in acne and correlated with inflammatory comedone counts. We then established a mouse model that faithfully recapitulates human acne phenotypes, in which topical C16:0 penetrated the epidermis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1062173e-9799-59de-87cd-f67be3c1c298
DOI: 10.1101/2025.08.30.673221

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A lipid-driven, microbe-independent mechanism of acne via <i> Lrig1 <sup>+</sup> </i> follicular progenitor cellsDOI 10.1101/2025.08.30.673221Read

Short-Chain Fatty Acids from <i>Cutibacterium acnes</i> Activate Both a Canonical and Epigenetic Inflammatory Response in Human SebocytesSemantic proximity Read

IL-17 <sup>+</sup> mast cell/T helper cell axis in the early stages of acneSemantic proximity Read

Spatial transcriptomics reveals altered lipid metabolism and inflammation-related gene expression of sebaceous glands in psoriasis and atopic dermatitisSemantic proximity Read

Current insights into skin lipids and their roles in cutaneous health and diseaseSemantic proximity Read

Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytesSemantic proximity Read

The role of lipid metabolism in acne risk: integrating blood metabolite and genetic insightsSemantic proximity Read

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesisSemantic proximity Read

Acylceramide is a key player in skin barrier function: insight into the molecular mechanisms of skin barrier formation and ichthyosis pathogenesisSemantic proximity Read

Lipid abnormalities in atopic skin are driven by type 2 cytokinesSemantic proximity Read

Multi-modal skin atlas identifies a multicellular immune-stromal community associated with altered cornification and specific T cell expansion in atopic dermatitisSemantic proximity Read

Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disordersSemantic proximity Read

The Inflammatory Basis of Acne Pathogenesis.Semantic proximity Read