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Article

The Role of KEAP1-NRF2 System in Atopic Dermatitis and Psoriasis

19 Jul 2022

Abstract excerpt

The Kelch-like erythroid cell-derived protein with cap'n'collar homology-associated protein 1 (KEAP1)-nuclear factor erythroid-2-related factor 2 (NRF2) system, a thiol-based sensor-effector apparatus, exerts antioxidative and anti-inflammatory effects and maintains skin homeostasis. Thus, NRF2 activation appears to be a promising treatment option for various skin diseases. However, NRF2-mediated defense...

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PMID: 35883888
DOI: 10.3390/antiox11071397

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