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Article

A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia

26 Oct 2014

Abstract excerpt

Dermal infiltration of T cells is an important step in the onset and progression of immune-mediated skin diseases such as psoriasis; however, it is not known whether epidermal factors play a primary role in the development of these diseases. Here, we determined that the prodifferentiation transcription factor grainyhead-like 3 (GRHL3), which is essential during epidermal development, is dispensable for adult skin...

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PMID: 25347468
DOI: 10.1172/jci77138

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