Article
Chronic oral administration of Ang-(1-7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy.
Clinical science (London, England : 1979) - 1 Jul 2014
Sabharwal Rasna, Cicha Michael Z, Sinisterra Ruben D M, De Sousa Frederico B, Santos Robson A, Chapleau Mark W
Abstract excerpt
Muscular dystrophies are a group of heterogeneous genetic disorders that cause progressive muscle weakness and wasting, dilated cardiomyopathy and early mortality. There are different types of muscular dystrophies with varying aetiologies but they all have a common hallmark of myofibre degeneration, atrophy and decreased mobility. Mutation in Sgcd (sarcoglycan-δ), a subunit of dystrophin glycoprotein complex,...
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