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Article

C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.

Cardiovascular research - 1 Dec 2016

Buttgereit Jens, Shanks Julia, Li Dan, Hao Guoliang, Athwal Arvinder, Langenickel Thomas H, Wright Hannah, da Costa Goncalves Andrey C, Monti Jan, Plehm Ralph, Popova Elena, Qadri Fatimunnisa, Lapidus Irina, Ryan Brent, Özcelik Cemil, Paterson David J, Bader Michael, Herring Neil

Abstract excerpt

AIMS: B-type natriuretic peptide (BNP)-natriuretic peptide receptor A (NPR-A) receptor signalling inhibits cardiac sympathetic neurotransmission, although C-type natriuretic peptide (CNP) is the predominant neuropeptide of the nervous system with expression in the heart and vasculature. We hypothesized that CNP acts similarly to BNP, and that transgenic rats (TGRs) with neuron-specific overexpression of a...

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Source

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Identifiers

PMID: 27496871
DOI: 10.1093/cvr/cvw184
PMCID: PMC5157132

Genes

CNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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