Article
Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein.
Clinical science (London, England : 1979) - 30 Sept 2021
Alves Daniele T, Mendes Luiz Felipe, Sampaio Walkyria O, Coimbra-Campos Leda M C, Vieira Maria Aparecida R, Ferreira Anderson J, Martins Almir S, Popova Elena, Todiras Mihail, Qadri Fatimunnisa, Alenina Natalia, Bader Michael, Santos Robson A S, Campagnole-Santos Maria Jose
Abstract excerpt
Activation of the angiotensin (Ang)-converting enzyme (ACE) 2/Ang-(1-7)/MAS receptor pathway of the renin-angiotensin system (RAS) induces protective mechanisms in different diseases. Herein, we describe the cardiovascular phenotype of a new transgenic rat line (TG7371) that expresses an Ang-(1-7)-producing fusion protein. The transgene-specific mRNA and the corresponding protein were shown to be present in all...
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