Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1-7) and Bradykinin.

Journal of diabetes research - 1 Jan 2015

Bertoncello Nádia, Moreira Roseli Peres, Arita Danielle Yuri, Aragão Danielle S, Watanabe Ingrid Kazue Mizuno, Dantas Patricia S, Santos Ralmony, Mattar-Rosa Rodolfo, Yokota Rodrigo, Cunha Tatiana Sousa, Casarini Dulce Elena

Abstract excerpt

Population studies have shown an association between diabetic nephropathy (DN) and insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene (ACE in humans, Ace in mice). The aim was to evaluate the modulation of Ace copies number and diabetes mellitus (DM) on renal RAS and correlate it with indicators of kidney function. Increased number of copies of the Ace gene, associated with DM,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Bradykinin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Experimental

Share to Diabetic Nephropathies

Share to Gene Dosage

Share to Peptidyl-Dipeptidase A

Share to Renin-Angiotensin System

Share to Spectrometry, Fluorescence

Source

Open in PubMed Open full text

Identifiers

PMID: 26442284
DOI: 10.1155/2015/674047
PMCID: PMC4579315

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1-7) and Bradykinin.PMID 26442284Read ↗

Angiotensin I-converting enzyme: a pathogenetic role in diabetic renal damage?Semantic proximity Read ↗

Genetically increased angiotensin I-converting enzyme alters peripheral and renal vascular reactivity to angiotensin II and bradykinin in mice.Semantic proximity Read ↗

Angiotensin-Converting Enzyme Gene Mutations, Blood Pressures, and Cardiovascular HomeostasisSemantic proximity Read ↗

Time to consider ACE insertion/deletion genotypes and individual renoprotective treatment in diabetic nephropathy?Semantic proximity Read ↗

Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme.Semantic proximity Read ↗

Influence of insertion/deletion polymorphism in the ACE-I gene on the progression of diabetic glomerulopathy in type 1 diabetic patients with microalbuminuria.Semantic proximity Read ↗

Effect of hypertension on angiotensin-(1-7) levels in rats with different angiotensin-I converting enzyme polymorphism.Semantic proximity Read ↗

ACE2/ANG-(1-7)/Mas receptor axis activation prevents inflammation and improves cognitive functions in streptozotocin induced rat model of Alzheimer's disease-like phenotypes.Semantic proximity Read ↗

Renal renin activity in recombinant inbred strains is related to abnormal renin gene: the role of blood pressure changes.Semantic proximity Read ↗

Ace gene dosage influences the development of renovascular hypertension.Semantic proximity Read ↗

Influence of gender and genetic variability on plasma angiotensin peptides.Semantic proximity Read ↗

G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB/N mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.