Article
ACE2/ANG-(1-7)/Mas receptor axis activation prevents inflammation and improves cognitive functions in streptozotocin induced rat model of Alzheimer's disease-like phenotypes.
European journal of pharmacology - 5 May 2023
Tiwari Virendra, Singh Jitendra, Tiwari Priya, Chaturvedi Swati, Gupta Shivangi, Mishra Akanksha, Singh Sonu, Wahajuddin Muhammad, Hanif Kashif, Shukla Shubha
Abstract excerpt
Activation of the renin-angiotensin system (RAS), by Angiotensin converting enzyme/Angiotensin II/Angiotensin receptor-1 (ACE/Ang II/AT1 R) axis elicits amyloid deposition and cognitive impairment. Furthermore, ACE2 induced release of Ang-(1-7) binds with the Mas receptor and autoinhibits ACE/Ang II/AT1 axis activation. Inhibition of ACE by perindopril has been reported to improve memory in preclinical settings....
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