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Article

Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase.

Science signaling - 1 Mar 2016

Irani Seema, Yogesha S D, Mayfield Joshua, Zhang Mengmeng, Zhang Yong, Matthews Wendy L, Nie Grace, Prescott Nicholas A, Zhang Yan Jessie

Abstract excerpt

Changes in the phosphorylation status of the carboxyl-terminal domain (CTD) of RNA polymerase II (RNAPII) correlate with the process of eukaryotic transcription. The yeast protein regulator of transcription 1 (Rtr1) and the human homolog RNAPII-associated protein 2 (RPAP2) may function as CTD phosphatases; however, crystal structures of Kluyveromyces lactis Rtr1 lack a consensus active site. We identified a...

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Identifiers

PMID: 26933063
DOI: 10.1126/scisignal.aad4805
PMCID: PMC4801511

Genes

RPAP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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