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Article

Case-only gene-environment interaction between ALAD tagSNPs and occupational lead exposure in prostate cancer.

The Prostate - 1 May 2014

Neslund-Dudas Christine, Levin Albert M, Rundle Andrew, Beebe-Dimmer Jennifer, Bock Cathryn H, Nock Nora L, Jankowski Michelle, Datta Indrani, Krajenta Richard, Dou Q Ping, Mitra Bharati, Tang Deliang, Rybicki Benjamin A

Abstract excerpt

BACKGROUND: Black men have historically had higher blood lead levels than white men in the U.S. and have the highest incidence of prostate cancer in the world. Inorganic lead has been classified as a probable human carcinogen. Lead (Pb) inhibits delta-aminolevulinic acid dehydratase (ALAD), a gene recently implicated in other genitourinary cancers. The ALAD enzyme is involved in the second step of heme...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24500903
DOI: 10.1002/pros.22781
PMCID: PMC4112406

Genes

ALAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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