Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead.

doi:10.1371/journal.pone.0020432

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Article

Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead.

PloS one - 1 Jan 2011

van Bemmel Dana M, Boffetta Paolo, Liao Linda M, Berndt Sonja I, Menashe Idan, Yeager Meredith, Chanock Stephen, Karami Sara, Zaridze David, Matteev Vsevolod, Janout Vladimir, Kollarova Hellena, Bencko Vladimir, Navratilova Marie, Szeszenia-Dabrowska Neonilia, Mates Dana, Slamova Alena, Rothman Nathaniel, Han Summer S, Rosenberg Philip S, Brennan Paul, Chow Wong-Ho, Moore Lee E

Abstract excerpt

BACKGROUND: Epidemiologic studies are reporting associations between lead exposure and human cancers. A polymorphism in the 5-aminolevulinic acid dehydratase (ALAD) gene affects lead toxicokinetics and may modify the adverse effects of lead. METHODS: The objective of this study was to evaluate single-nucleotide polymorphisms (SNPs) tagging the ALAD region among renal cancer cases and controls to determine whether...

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PMID: 21799727
DOI: 10.1371/journal.pone.0020432
PMCID: PMC3140467

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ALAD

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