Article
Lead, genetic susceptibility, and risk of adult brain tumors.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2006
Rajaraman Preetha, Stewart Patricia A, Samet Jonathan M, Schwartz Brian S, Linet Martha S, Zahm Shelia Hoar, Rothman Nathaniel, Yeager Meredith, Fine Howard A, Black Peter M, Loeffler Jay, Shapiro William R, Selker Robert G, Inskip Peter D
Abstract excerpt
BACKGROUND: Although few etiologic factors for brain tumors have been identified, limited data suggest that lead may increase the risk of brain tumors, particularly meningioma. The ALAD G177C polymorphism affects the toxicokinetics of lead and may confer genetic susceptibility to adverse effects of lead exposure. METHODS: We examined occupational exposure to lead and risk of brain tumors in a multisite,...
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