Article
FLT3-ITD mutation in relation to FLT3 expression in pediatric AML: a prospective study from India.
Pediatric hematology and oncology - 1 Mar 2014
Sharawat Surender Kumar, Bakhshi Radhika, Vishnubhatla Sreenivas, Gupta Ritu, Bakhshi Sameer
Abstract excerpt
There is lack of data with regard to FLT3 expression in FLT3-ITD positive pediatric AML patients. Further, FLT3-ITD has not been systematically analyzed for outcome from Indian subcontinent. Amongst 64 consecutive pediatric AML patients, FLT3-ITD was present in 12 (19%) patients. All patients with FLT3-ITD achieved CR; those with FLT3-ITD mutation had inferior DFS (P = .029). FLT3 expression by flow-cytometry was...
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