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Article

Clinical implications of FLT3 mutations in pediatric AML.

Blood - 1 Dec 2006

Meshinchi Soheil, Alonzo Todd A, Stirewalt Derek L, Zwaan Michel, Zimmerman Martin, Reinhardt Dirk, Kaspers Gertjan J L, Heerema Nyla A, Gerbing Robert, Lange Beverly J, Radich Jerald P

Abstract excerpt

Activating mutations of the FLT3 gene occur because of an internal tandem duplication of the juxta-membrane domain (FLT3/ITD) or point mutation of the activation loop domain (FLT3/ALM). The presence of FLT3 mutations as well as the allelic ratio of FLT3/ITD (ITD-AR, mutant-wild type ratio) may have prognostic significance. FLT3 mutation status of 630 children with de novo acute myeloid leukemia (AML) treated on...

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Source

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Identifiers

PMID: 16912228
DOI: 10.1182/blood-2006-03-009233
PMCID: PMC1895470

Genes

FLT3

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Clinical implications of FLT3 mutations in pediatric AML.PMID 16912228Read ↗

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