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Article

Impairment of ribosomes and DNA biosynthesis confers resistance to Inhibition of sphingolipid biosynthesis.

Molecular genetics and genomics : MGG - 31 Jan 2026

Yamagata Satomi, Sugihara Saki, Kawaguchi Takahiro, Matsuzaki Momoko, Tabuchi Mitsuaki, Tani Motohiro

Abstract excerpt

Sphingolipids are essential components of eukaryotic membranes and play central roles in cellular growth and stress responses. In the budding yeast Saccharomyces cerevisiae, Lcb1 and Lcb2 constitute the serine palmitoyltransferase complex, which catalyzes the initial step of sphingolipid biosynthesis. Repression of LCB1 expression leads to inhibition of sphingolipid biosynthesis, resulting in severe growth...

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Identifiers

PMID: 41619027
DOI: 10.1007/s00438-025-02337-4

Genes

RPL35A

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