Article
Unregulated Sphingolipid Biosynthesis in Gene-Edited Arabidopsis ORM Mutants Results in Nonviable Seeds with Strongly Reduced Oil Content.
The Plant cell - 1 Aug 2020
Gonzalez-Solis Ariadna, Han Gongshe, Gan Lu, Li Yunfeng, Markham Jennifer E, Cahoon Rebecca E, Dunn Teresa M, Cahoon Edgar B
Abstract excerpt
Orosomucoid-like proteins (ORMs) interact with serine palmitoyltransferase (SPT) to negatively regulate sphingolipid biosynthesis, a reversible process critical for balancing the intracellular sphingolipid levels needed for growth and programmed cell death. Here, we show that ORM1 and ORM2 are essential for life cycle completion in Arabidopsis (Arabidopsis thaliana). Seeds from orm1 -/- orm2 -/- mutants,...
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