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Article

Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau.

Journal of neuropathology and experimental neurology - 1 May 2009

Perreault Sébastien, Bousquet Olivier, Lauzon Michel, Paiement Jacques, Leclerc Nicole

Abstract excerpt

In several neurodegenerative diseases, including Alzheimer disease, the neuronal microtubule-associated protein tau becomes hyperphosphorylated, accumulates in the somatodendritic compartment, and aggregates into insoluble filaments. The consequences of the accumulation of hyperphosphorylated tau in the somatodendritic compartment remain poorly characterized at the early stage of disease before the formation of...

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PMID: 19525898
DOI: 10.1097/NEN.0b013e3181a1fc49

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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