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Article

Assessment of age-related changes in heritability and IGF-1 gene effect on circulating IGF-1 levels.

Age (Dordrecht, Netherlands) - 1 Jun 2014

Franco Liran, Williams Frances M K, Trofimov Svetlana, Malkin Ida, Surdulescu Gabriela, Spector Timothy, Livshits Gregory

Abstract excerpt

It is well established that insulin-like growth factor 1 (IGF-1) circulating levels correlate with age and that heritability and influence of IGF-1 gene variation on IGF-1 levels also well-known. However, the influence of age on the genetic factors determining IGF-1 levels is not clear. In this study, we compared heritability estimates between younger (<52 years) and older (>52 years) twins and tested: (a)...

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Identifiers

PMID: 24493200
DOI: 10.1007/s11357-014-9622-7
PMCID: PMC4082604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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