Insulinlike Growth Factor 1 Gene Variation in Vertebrates.

doi:10.1210/en.2018-00259

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Article

Insulinlike Growth Factor 1 Gene Variation in Vertebrates.

Endocrinology - 1 Jun 2018

Rotwein Peter

Abstract excerpt

IGF1-a small, single-chain, secreted peptide in mammals-is essential for normal somatic growth and is involved in a variety of other physiological and pathophysiological processes. IGF1 expression appears to be controlled by several different signaling mechanisms in mammals, with GH playing a key role by activating an inducible transcriptional pathway via the Jak2 protein kinase and the Stat5b transcription...

Topics

Animals
Evolution, Molecular
Exons
Genetic Variation
Humans
Insulin-Like Growth Factor I
Introns
Promoter Regions, Genetic
Sequence Analysis, DNA
Vertebrates

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Identifiers

PMID: 29697760
DOI: 10.1210/en.2018-00259
PMCID: PMC6692883

Genes

IGF1

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