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Article

Sequence variation in IGF1R is associated with differences in insulin levels in nondiabetic Old Order Amish.

Diabetes/metabolism research and reviews - 1 Nov 2009

Naj Adam C, Kao Wen-Hong L, O'Connell Jeffrey R, Mitchell Braxton D, Silver Kristi D

Abstract excerpt

BACKGROUND: Insulin growth factor-1 receptor (IGF1R) encodes the insulin-like growth factor 1 receptor, a transmembrane tyrosine kinase receptor located on chromosome 15q26.3, in a region of linkage (LOD = 2.53, P = 0.00032) to Insulin30 on an OGTT in the Old Order Amish. Mouse models with beta-cell-specific deficiency of IGF1R demonstrate defects in glucose-stimulated insulin secretion. METHODS: To test the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19877134
DOI: 10.1002/dmrr.1044
PMCID: PMC2837841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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