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Article

Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes.

European journal of human genetics : EJHG - 1 Jan 2006

Rodríguez Santiago, Gaunt Tom R, Dennison Elaine, Chen Xiao-he, Syddall Holly E, Phillips David I W, Cooper Cyrus, Day Ian N M

Abstract excerpt

Interindividual variation of the IGF2-INS-TH region influences risk of a variety of diseases and complex traits. Previous studies identified a haplotype (designated IGF2-INS-TH(*)5 and tagged by allele A of IGF2 ApaI, allele 9 of TH01 and class I alleles of INS VNTR) associated with low body mass index (BMI) in a cohort of UK men. We aimed here both to study whether previous findings relating (*)5 with weight are...

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Source

Identifiers

PMID: 16251897
DOI: 10.1038/sj.ejhg.5201505

Genes

IGF2
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes.PMID 16251897Read ↗

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IGF2BP1, IGF2BP2 and IGF2BP3 genotype, haplotype and genetic model studies in metabolic syndrome traits and diabetes.Semantic proximity Read ↗

Evidence of multiple causal sites affecting weight in the IGF2-INS-TH region of human chromosome 11.Semantic proximity Read ↗

Association of sequence variations in the gene encoding insulin-like growth factor binding protein 5 with adiponectin.Semantic proximity Read ↗

A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study.Semantic proximity Read ↗

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Associations of IGF2 ApaI RFLP and INS VNTR class I allele size with obesity.Semantic proximity Read ↗

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