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Article

CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype.

Journal of translational medicine - 25 Nov 2021

Ma Jingchang, Hu Wei, Zhang Dongliang, Xie Jiangang, Duan Chujun, Liu Yitian, Wang Yuling, Xu Xuexue, Cheng Kun, Jin Boquan, Zhang Yuan, Zhuang Ran

Abstract excerpt

Obesity is associated with chronic low-grade inflammation, contributing to an increasing prevalence of chronic metabolic diseases, such as insulin resistance, non-alcoholic fatty liver disease (NALFD), and steatohepatitis. Macrophages are the predominant immune cells in adipose tissues. Adipose tissue macrophages (ATMs) would switch to pro-inflammatory M1 state during obesity, causing local and systemic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34823548
DOI: 10.1186/s12967-021-03150-4
PMCID: PMC8620575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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