Article

Adipocyte OX40L Promotes Adipose T Cell Activation and Insulin Resistance in Obesity

2025-09-01

Abstract excerpt

<title>Abstract</title> <p>T cells contribute critically to obesity-induced adipose inflammation and insulin resistance, yet the co-stimulatory signals that govern their activation in adipose tissue remain unclear. Here, we systematically profile co-stimulatory molecules in adipocytes and adipose tissue macrophages and identify OX40 ligand (OX40L) as the most robustly upregulated in obesity. OX40L is also elevate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f77fd3c-34df-53d8-b50e-f3bcd613f3ea
DOI: 10.21203/rs.3.rs-7361491/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adipocyte OX40L Promotes Adipose T Cell Activation and Insulin Resistance in ObesityDOI 10.21203/rs.3.rs-7361491/v1Read

Rapid adipose tissue expansion triggers proliferation of memory adipose tissue T cells and accumulation of novel T helper 2 (Th2) regulatory cellsSemantic proximity Read

The Immune Landscape of Visceral Adipose Tissue During Obesity and AgingSemantic proximity Read

Cell-cell crosstalk between fat cells and immune cellsSemantic proximity Read

Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissueSemantic proximity Read

Adipose stem cells control obesity-induced T cell infiltration into adipose tissueSemantic proximity Read

Immune cell–adipose tissue crosstalk in metabolic diseases with a focus on type 1 diabetesSemantic proximity Read

The Interplay between Obesity and InflammationSemantic proximity Read

Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytesSemantic proximity Read

Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states.Semantic proximity Read

MicroRNAs: a crossroad that connects obesity to immunity and agingSemantic proximity Read

Adipose tissue macrophages: implications for obesity-associated cancerSemantic proximity Read

Innate-Immunity Genes in ObesitySemantic proximity Read