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Article

Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease

15 Feb 2019

Abstract excerpt

Identifying regulatory mechanisms that influence inflammation in metabolic tissues is critical for developing novel metabolic disease treatments. Here, we investigated the role of microRNA-146a (miR-146a) during diet-induced obesity in mice. miR-146a is reduced in obese and type 2 diabetic patients and our results reveal that miR-146a-/- mice fed a high-fat diet (HFD) have exaggerated weight gain, increased...

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PMID: 30768595
DOI: 10.1371/journal.pgen.1007970

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