Article
Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.
Nature communications - 24 Jul 2020
Toubal Amine, Kiaf Badr, Beaudoin Lucie, Cagninacci Lucie, Rhimi Moez, Fruchet Blandine, da Silva Jennifer, Corbett Alexandra J, Simoni Yannick, Lantz Olivier, Rossjohn Jamie, McCluskey James, Lesnik Philippe, Maguin Emmanuelle, Lehuen Agnès
Abstract excerpt
Obesity is associated with low-grade chronic inflammation promoting insulin-resistance and diabetes. Gut microbiota dysbiosis is a consequence as well as a driver of obesity and diabetes. Mucosal-associated invariant T cells (MAIT) are innate-like T cells expressing a semi-invariant T cell receptor restricted to the non-classical MHC class I molecule MR1 presenting bacterial ligands. Here we show that during...
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