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Article

In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation.

mAbs - 1 Jan 2000

Li Bing, Fouts Ashley E, Stengel Katharina, Luan Peng, Dillon Michael, Liang Wei-Ching, Feierbach Becket, Kelley Robert F, Hötzel Isidro

Abstract excerpt

Antibodies isolated from human donors are increasingly being developed for anti-infective therapeutics. These antibodies undergo affinity maturation in vivo, minimizing the need for engineering of therapeutic leads for affinity. However, the affinities required for some therapeutic applications may be higher than the affinities of the leads obtained, requiring further affinity maturation in vitro. To improve the...

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Identifiers

PMID: 24492299
DOI: 10.4161/mabs.27875
PMCID: PMC3984332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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