Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries

Abstract excerpt

The early phase of protein drug development has traditionally focused on target binding properties leading to a desired mode of therapeutic action. As more protein therapeutics pass through the development pipeline; however, it is clear that non-optimal biophysical properties can emerge, particularly as proteins are formulated at high concentrations, causing aggregation or polyreactivity. Such late-stage...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Advanced Biosensing Techniques and Applications
• Share to Monoclonal and Polyclonal Antibodies Research
• Share to Viral Infectious Diseases and Gene Expression in Insects