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Article

Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage.

Proteins - 1 Apr 2015

Xu Huafeng, Schmidt Aaron G, O'Donnell Timothy, Therkelsen Matthew D, Kepler Thomas B, Moody M Anthony, Haynes Barton F, Liao Hua-Xin, Harrison Stephen C, Shaw David E

Abstract excerpt

Affinity maturation, the process in which somatic hypermutation and positive selection generate antibodies with increasing affinity for an antigen, is pivotal in acquired humoral immunity. We have studied the mechanism of affinity gain in a human B-cell lineage in which two main maturation pathways, diverging from a common ancestor, lead to three mature antibodies that neutralize a broad range of H1 influenza...

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Share to Antibodies, Neutralizing
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Binding Sites, Antibody

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Source

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Identifiers

PMID: 25524709
DOI: 10.1002/prot.24745
PMCID: PMC4368477

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