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Article

The Wnt/β-catenin pathway regulates growth and maintenance of colonospheres

6 Aug 2010

Abstract excerpt

BACKGROUND: Recent evidence suggests that epithelial cancers, including colorectal cancer are driven by a small sub-population of self-renewing, multi-potent cells termed cancer stem cells (CSCs) which are thought to be responsible for recurrence of cancer. One of the characteristics of CSCs is their ability to form floating spheroids under anchorage-independent conditions in a serum-free defined media. The...

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PMID: 20691072
DOI: 10.1186/1476-4598-9-212

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