Article

Aspirin-mediated DKK-1 increase rescues Wnt-driven stem-like phenotype in human intestinal organoids

2019-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Aspirin reduces the incidence and mortality of colorectal cancer (CRC). Wnt signalling drives CRC development from initiation to progression through regulation of epithelial-mesenchymal transition (EMT) and cancer stem cell populations (CSC). Here, we investigated whether aspirin can rescue these pro-invasive phenotypes associated with CRC progression in Wnt-driven human and mouse intestinal org...

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Literature Corpus work: 3d014ba5-0b88-5356-b129-8bcdb005cdc2
DOI: 10.1101/809517

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