Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis.

PloS one - 1 Jan 2013

Ghazvini Mehrnaz, Sonneveld Petra, Kremer Andreas, Franken Patrick, Sacchetti Andrea, Atlasi Yaser, Roth Sabrina, Joosten Rosalie, Smits Ron, Fodde Riccardo

Abstract excerpt

Constitutive activation of the Wnt pathway leads to adenoma formation, an obligatory step towards intestinal cancer. In view of the established role of Wnt in regulating stemness, we attempted the isolation of cancer stem cells (CSCs) from Apc- and Apc/KRAS-mutant intestinal tumours. Whereas CSCs are present in Apc/KRAS tumours, they appear to be very rare (<10(-6)) in the Apc-mutant adenomas. In contrast, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to CD24 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, APC

Share to Immunophenotyping

Share to Integrin beta1

Share to Intestinal Neoplasms

Share to Intracellular Space

Share to Neoplastic Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 24069241
DOI: 10.1371/journal.pone.0073872
PMCID: PMC3775784

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis.PMID 24069241Read ↗

Wnt signaling in cancer stem cells and colon cancer metastasisSemantic proximity Read ↗

Stem vs non-stem cell origin of colorectal cancer.Semantic proximity Read ↗

Colonic and colorectal cancer stem cells: progress in the search for putative biomarkersSemantic proximity Read ↗

CD44‐positive colorectal adenoma cells express the potential stem cell markers musashi antigen (msi1) and ephrin B2 receptor (EphB2)Semantic proximity Read ↗

Paneth cells as the origin of intestinal cancer in the context of inflammationSemantic proximity Read ↗

Targeting Wnt Signaling in Colon Cancer Stem CellsSemantic proximity Read ↗

Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation.Semantic proximity Read ↗

Wnt signaling in adult intestinal stem cells and cancerSemantic proximity Read ↗

Stem cells and their implications for colorectal cancer.Semantic proximity Read ↗

Therapeutic implications of colon cancer stem cellsSemantic proximity Read ↗

Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling.Semantic proximity Read ↗

CD133 as a target for colon cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.