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Article

Confirmation of warfarin resistance of naturally occurring VKORC1 variants by coexpression with coagulation factor IX and in silico protein modelling.

BMC genetics - 4 Feb 2014

Müller Elisabeth, Keller Alexander, Fregin Andreas, Müller Clemens R, Rost Simone

Abstract excerpt

BACKGROUND: VKORC1 has been identified some years ago as the gene encoding vitamin K epoxide reductase (VKOR) - the target protein for coumarin derivates like warfarin or phenprocoumon. Resistance against warfarin and other coumarin-type anticoagulants has been frequently reported over the last 50 years in rodents due to problems in pest control as well as in thrombophilic patients showing variable response to...

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Source

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Identifiers

PMID: 24491178
DOI: 10.1186/1471-2156-15-17
PMCID: PMC3927768

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Confirmation of warfarin resistance of naturally occurring VKORC1 variants by coexpression with coagulation factor IX and in silico protein modelling.PMID 24491178Read ↗

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