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Article

Delayed Repair of DNA Damage by Ionizing Radiation in Cells from Patients with Juvenile Systemic Lupus Erythematosus and Rheumatoid Arthritis

1 Jan 1997

Abstract excerpt

We used a single-cell alkaline gel electrophoresis (SCAGE) assay to study repair of primarily single-stranded DNA breaks after in vitro exposure to ionizing radiation in cells from children with systemic lupus erythematosus (SLE), juvenile rheumatoid arthritis (JRA), systemic sclerosis (SSc) and dermatomyositis. Peripheral blood lymphocytes from patients with SLE, JRA and SSc had significantly greater DNA damage...

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PMID: 8989369
DOI: 10.2307/3579442

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