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Article

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.

Acta neuropathologica communications - 30 Jan 2014

Dujardin Simon, Lécolle Katia, Caillierez Raphaëlle, Bégard Séverine, Zommer Nadège, Lachaud Cédrick, Carrier Sébastien, Dufour Noëlle, Aurégan Gwennaëlle, Winderickx Joris, Hantraye Philippe, Déglon Nicole, Colin Morvane, Buée Luc

Abstract excerpt

BACKGROUND: In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain, the hierarchical pathways of this neurodegeneration have been well established in Alzheimer's disease (AD) and other sporadic tauopathies such as argyrophilic grain disorder and progressive supranuclear palsy but the molecular and cellular...

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Identifiers

PMID: 24479894
DOI: 10.1186/2051-5960-2-14
PMCID: PMC3922636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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