Article
Predicting HLA genotypes using unphased and flanking single-nucleotide polymorphisms in Han Chinese population.
BMC genomics - 29 Jan 2014
Hsieh Ai-Ru, Chang Su-Wei, Chen Pei-Lung, Chu Chen-Chung, Hsiao Ching-Lin, Yang Wei-Shiung, Chang Chien-Ching, Wu Jer-Yuarn, Chen Yuan-Tsong, Chang Tien-Chun, Fann Cathy Sj
Abstract excerpt
BACKGROUND: Genetic variation associated with human leukocyte antigen (HLA) genes has immunological functions and is associated with autoimmune diseases. To date, large-scale studies involving classical HLA genes have been limited by time-consuming and expensive HLA-typing technologies. To reduce these costs, single-nucleotide polymorphisms (SNPs) have been used to predict HLA-allele types. Although HLA allelic...
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