Article
Development of obesity and insulin resistance in the Israeli sand rat (Psammomys obesus). Does leptin play a role?
Annals of the New York Academy of Sciences - 20 Sept 1997
Collier G R, De Silva A, Sanigorski A, Walder K, Yamamoto A, Zimmet P
Abstract excerpt
The Israeli Sand Rat (Psammomys obesus) is an excellent polygenic model for the study of obesity and diabetes. The metabolic characteristics and the heterogeneous development of these defects, including elevated leptin levels, mimic those found in susceptible human populations. Interestingly, only animals that develop metabolic abnormalities demonstrate hyperleptinemia and, in these animals, leptin administration...
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