Article
The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity.
Endocrinology - 1 Jan 2011
Childs Gwen V, Akhter Noor, Haney Anessa, Syed Mohsin, Odle Angela, Cozart Michael, Brodrick Zachary, Gaddy Dana, Suva Larry J, Akel Nisreen, Crane Christopher, Benes Helen, Charlesworth Amanda, Luque Raul, Chua Streamson, Kineman Rhonda D
Abstract excerpt
Leptin, the product of the Lep gene, reports levels of adiposity to the hypothalamus and other regulatory cells, including pituitary somatotropes, which secrete GH. Leptin deficiency is associated with a decline in somatotrope numbers and function, suggesting that leptin may be important in their...
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