Navigating the Strengths and Constraints of Mouse Models in Obesity Research

Abstract excerpt

Obesity is a major health problem, being a risk factor for many metabolic diseases. Obesity results from an imbalance in energy intake and energy expenditure. Animal models, particularly naturally occurring mouse models of obesity, have provided a framework of the basic mechanisms regulating energy homeostasis. However, there remain gaps in our understanding of the mechanisms underlying the pathophysiology of...