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Article

Neuropeptidergic characterization of the leptin receptor mutated obese Koletsky rat.

Regulatory peptides - 15 Jun 2004

Keen Rhinehart Erin, Kalra Satya P, Kalra Pushpa S

Abstract excerpt

Leptin regulates energy homeostasis and reproduction as evidenced by dysfunctions characterized in several genetic models of leptin pathway deficiency, such as the ob/ob and db/db mice and fa/fa Zucker rat. An additional model, the obese (f/f) Koletsky rat with a nonsense leptin receptor mutation has not been fully characterized. These rats are obese, hyperphagic, diabetic, and infertile; however, little else is...

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Identifiers

PMID: 15093691
DOI: 10.1016/j.regpep.2003.12.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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