Article
Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase.
Nature chemical biology - 1 Mar 2014
Matthews Megan L, Chang Wei-chen, Layne Andrew P, Miles Linde A, Krebs Carsten, Bollinger J Martin
Abstract excerpt
Iron-dependent halogenases employ cis-halo-Fe(IV)-oxo (haloferryl) complexes to functionalize unactivated aliphatic carbon centers, a capability elusive to synthetic chemists. Halogenation requires (i) coordination of a halide anion (Cl(-) or Br(-)) to the enzyme's Fe(II) cofactor, (ii) coupled activation of O2 and decarboxylation of α-ketoglutarate to generate the haloferryl intermediate, (iii) abstraction of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.