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Article

Structural basis for divergent C-H hydroxylation selectivity in two Rieske oxygenases.

Nature communications - 12 Jun 2020

Lukowski April L, Liu Jianxin, Bridwell-Rabb Jennifer, Narayan Alison R H

Abstract excerpt

Biocatalysts that perform C-H hydroxylation exhibit exceptional substrate specificity and site-selectivity, often through the use of high valent oxidants to activate these inert bonds. Rieske oxygenases are examples of enzymes with the ability to perform precise mono- or dioxygenation reactions on a variety of substrates. Understanding the structural features of Rieske oxygenases responsible for control over...

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Identifiers

PMID: 32532989
DOI: 10.1038/s41467-020-16729-0
PMCID: PMC7293229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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