Article
The oxidative inactivation of FeFe hydrogenase reveals the flexibility of the H-cluster.
Nature chemistry - 1 Apr 2014
Fourmond Vincent, Greco Claudio, Sybirna Kateryna, Baffert Carole, Wang Po-Hung, Ezanno Pierre, Montefiori Marco, Bruschi Maurizio, Meynial-Salles Isabelle, Soucaille Philippe, Blumberger Jochen, Bottin Hervé, De Gioia Luca, Léger Christophe
Abstract excerpt
Nature is a valuable source of inspiration in the design of catalysts, and various approaches are used to elucidate the mechanism of hydrogenases, the enzymes that oxidize or produce H2. In FeFe hydrogenases, H2 oxidation occurs at the H-cluster, and catalysis involves H2 binding on the vacant coordination site of an iron centre. Here, we show that the reversible oxidative inactivation of this enzyme results from...
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