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Article

Oxygen Activation Switch in the Copper Amine Oxidase of Escherichia coli.

Biochemistry - 11 Sept 2018

Gaule Thembaninkosi G, Smith Mark A, Tych Katarzyna M, Pirrat Pascale, Trinh Chi H, Pearson Arwen R, Knowles Peter F, McPherson Michael J

Abstract excerpt

Copper amine oxidases (CuAOs) are metalloenzymes that reduce molecular oxygen to hydrogen peroxide during catalytic turnover of primary amines. In addition to Cu2+ in the active site, two peripheral calcium sites, ∼32 Å from the active site, have roles in Escherichia coli amine oxidase (ECAO). The buried Ca2+ (Asp533, Leu534, Asp535, Asp678, and Ala679) is essential for full-length protein production, while the...

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Identifiers

PMID: 30110143
DOI: 10.1021/acs.biochem.8b00633
PMCID: PMC6136094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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