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Mutagenic Survey of Key Residues of NifB Involved in Radical SAM-Dependent Nitrogenase Cofactor Assembly.

Chembiochem : a European journal of chemical biology - 15 Jun 2026

Duffin Calder, Quechol Robert, Yang Yimo, Lee Chi Chung, Hu Yilin, Ribbe Markus W

Abstract excerpt

NifB, a radical SAM enzyme, catalyzes the formation of a distinct [Fe8S9C] core (L-cluster) of the nitrogenase cofactor. Prior studies have led to the proposal of three [Fe4S4] modules-RS, K1, and K2-that mediate fusion of K1 and K2 via radical SAM chemistry at RS, but the identities and functions of cluster ligands and SAM-binding residues have remained unclear. Here, we report a systematic mutagenic analysis of...

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PMID: 42218797
DOI: 10.1002/cbic.70400

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