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Article

Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits.

Journal of neurochemistry - 1 Jun 2014

Ting Jenhao H, Marks David R, Schleidt Stephanie S, Wu Joanna N, Zyskind Jacob W, Lindl Kathryn A, Blendy Julie A, Pierce R Christopher, Jordan-Sciutto Kelly L

Abstract excerpt

Aberrant expression and activation of the cell cycle protein E2F1 in neurons has been implicated in many neurodegenerative diseases. As a transcription factor regulating G1 to S phase progression in proliferative cells, E2F1 is often up-regulated and activated in models of neuronal death. However...

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Identifiers

PMID: 24460902
DOI: 10.1111/jnc.12655
PMCID: PMC4028376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24460902-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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