Article
A Upf3b-mutant mouse model with behavioral and neurogenesis defects.
Molecular psychiatry - 1 Aug 2018
Huang L, Shum E Y, Jones S H, Lou C-H, Chousal J, Kim H, Roberts A J, Jolly L A, Espinoza J L, Skarbrevik D M, Phan M H, Cook-Andersen H, Swerdlow N R, Gecz J, Wilkinson M F
Abstract excerpt
Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specific contexts. NMD is regulated in a tissue-specific and developmentally controlled manner, raising the possibility that it influences developmental events. Indeed, loss or depletion of NMD factors have been shown to disrupt developmental events in organisms...
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