Article
Transmembrane protein 184B (TMEM184B) promotes expression of synaptic gene networks in the mouse hippocampus.
BMC genomics - 20 Sept 2023
Wright Elizabeth B, Larsen Erik G, Coloma-Roessle Cecilia M, Hart Hannah R, Bhattacharya Martha R C
Abstract excerpt
In Alzheimer's Disease (AD) and other dementias, hippocampal synaptic dysfunction and loss contribute to the progression of memory impairment. Recent analysis of human AD transcriptomes has provided a list of gene candidates that may serve as drivers of disease. One such candidate is the membrane protein TMEM184B. To evaluate whether TMEM184B contributes to neurological impairment, we asked whether loss of...
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