Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice.

Neurobiology of aging - 1 Feb 2018

Khan Mohammad Moshahid, Xiao Jianfeng, Patel Damini, LeDoux Mark S

Abstract excerpt

Cell-cycle dysfunction and faulty DNA repair are closely intertwined pathobiological processes that may contribute to several neurodegenerative disorders. CDKN1A interacting zinc finger protein 1 (CIZ1) plays a critical role in DNA replication and cell-cycle progression at the G1/S checkpoint. Germline or somatic variants in CIZ1 have been linked to several neural and extra-neural diseases. Recently, we showed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cognition
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, cdc

Share to Molecular Targeted Therapy

Share to Neurodegenerative Diseases

Share to NF-kappa B

Share to Oxidative Stress

Source

Open in PubMed Open full text

Identifiers

PMID: 29154038
DOI: 10.1016/j.neurobiolaging.2017.10.014
PMCID: PMC5877805

Genes

CIZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice.PMID 29154038Read ↗

Accelerated Age-Related Cognitive Decline and Neurodegeneration, Caused by Deficient DNA RepairSemantic proximity Read ↗

A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neuronsSemantic proximity Read ↗

Zbp1 gene: a modulator of multiple aging hallmarks as potential therapeutic target for age-related diseasesSemantic proximity Read ↗

Age-related motor neuron degeneration in DNA repair-deficient Ercc1 miceSemantic proximity Read ↗

Neuroinflammation links the neurogenic and neurodegenerative phenotypes of <i> Nrmt1 <sup>-/-</sup> </i> miceSemantic proximity Read ↗

Stress-Induced <i>PTBP1</i> Reprograms Neuronal Function and Activates Cellular SenescenceSemantic proximity Read ↗

The age-regulated zinc finger factor ZNF367 is a new modulator of embryonic neurogenesisSemantic proximity Read ↗

A Novel Role for BRIP1/FANCJ in Neuronal Cells Health and in Resolving Oxidative Stress-Induced DNA LesionsSemantic proximity Read ↗

NPC1 deficiency engages a lysosome–genome–immune program linked to neurodegeneration and cellular aging signaturesSemantic proximity Read ↗

Targeting CyclinD1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional DeclineSemantic proximity Read ↗

Chromosome Instability, Aging and Brain Diseases.Semantic proximity Read ↗

Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.