Article
Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila.
Human molecular genetics - 15 Jun 2014
Angeles Dario C, Ho Patrick, Chua Ling Ling, Wang Cheng, Yap Yan Wann, Ng Cheehoe, Zhou Zhi dong, Lim Kah-Leong, Wszolek Zbigniew K, Wang Hong Y, Tan Eng King
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) are common causes of familial Parkinson's disease (PD). LRRK2 has been shown to bind peroxiredoxin-3 (PRDX3), the most important scavenger of hydrogen peroxide in the mitochondria, in vitro. Here, we examined the interactions of LRRK2 and PRDX3 in Drosophila models by crossing transgenic LRRK2 and PRDX3 flies. As proof of principle experiments, we subsequently...
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